The primary risk factor for diseases such as macular degeneration, Parkinson’s and Alzheimer’s disease is age follow this web-site http://drugsildenafilbank.com . Although many researchers have sought better understand the genetics and pathophysiology of these diseases, few studies on basic on basic molecular mechanisms that control neuronal aging. Gilbert Bernier, the Universit? de Montr? al and Maisonneuve-Rosemont Hospital, led a team that have now found mice, which dramatically speeds up the aging process identified in the brain and the eye. The new study shows that neurons in the retina and require the cerebral cortex to prevent a gene called Bmi1 to activate the p53 pathway and the accumulation of free radicals. – ‘Overall, we have now determined that the Bmi1 gene is a direct regulator of cell aging in brain and retinal neurons of mammals through its action on the defense mechanisms against free radicals,’says Dr. Bernier.
About the survey:The article entitled The Polycomb group genes Bmi1 antioxidant defenses in neurons by inhibiting Regulates p53 Pro-Oxidant Activity , published in The Journal of Neuroscience, the work of Dr. Gilbert Bernier in collaboration with Wassim Chatoo, Mohammed Abdouh, Jocelyn David, Marie-Pier Champagne, Ferreira of the University? de Montr al and Maisonneuve-Rosemont Hospital with Francis Rodier from the Lawrence Berkeley National Laboratory, San Francisco, USA.
The research team is, including scientists from University of Utah and Stockholm’s Karolinska Institute, in vitro models. Of HIV-1 latency in T cells that host a full-length HIV genome within develops the provirus in the cell lines and a fluorescent tag for HIV-1 transcriptional activity illuminate coded.